Department of Chemistry and Biochemistry
Harper Cancer Research Institute
University of Notre Dame



Dan Scott’s JMB paper is featured on the cover! Congratulations Dan.

New graduate student Cory Ayres joins the lab – partially. Cory will be co-advised by Steve Corcelli, bringing expertise in computational chemistry to questions in biomolecular recognition. Welcome, Cory!

New paper in the Journal of Molecular Biology describing how the T cell receptor flexibility influences and controls specificity and cross-reactivity in the immune system.



New paper in the Journal of Biological Chemistry demonstrating that the poor activity of a melanoma vaccine candidate is attributable to how peptide manipulation enhances molecular flexibility. Implications for peptide vaccines in general.


New paper in the Journal of Biological Chemistry. A collaborative effort with Shahriar Mobashery, this paper is a new direction for the lab – mechanisms of bacterial antibiotic resistance.


New paper in the Journal of Immunology showing that different T cell receptors specific for tumor antigens can have divergent mechanisms of cross-reactivity.

New grant from the Walther Cancer Foundation, via the new Harper Cancer Center. Joint with Peter Velazquez at Indiana University School of Medicine, this grant will support our research into engineering T cells for cancer immunotherapy. Science – not fiction!

Kurt Piepenbrink is off to the University of Maryland for a postdoc with the immortal Eric Sundberg. He took Cyndy with him. How will we get any work done now?

New postdoc Lance Hellman joins the group. Welcome, Lance!


Kurt Piepenbrink successfully defends PhD thesis. Congratulations Dr. P!


Bill Hawse receives a prestigious postdoctoral fellowship from the American Cancer Society to support his research into the mechanisms of TCR binding and cross-reactivity using NMR and other biophysical tools. Congratulations Bill!

New paper in Protein Engineering, Design and Selection describing the molecular evolution of stable single chain constructs of T cell receptors. This is another in our ongoing collaboration with David Kranz at UIUC.


New paper in the Journal of Immunology exploring how cross-reactive T cells can escape negative selection through a combination of conformational changes and weak antigen presentation.

Oleg Borbulevych is off to a new job at the startup QuantumBio, integrating quantum chemistry into refinement of protein crystallography data. Good luck Oleg!


Francis Insaidoo off to a new postdoc at Columbia University. Congrats and good luck, Francis!